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KMID : 0882420090760020186
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Korean Journal of Medicine
2009 Volume.76 No. 2 p.186 ~ p.192
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The trend in the eradication rates of first- and second-line therapy for Helicobacter pylori infection in Daegu and Kyungpook provinces: a single center experience for the most recent 9 years
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Cho Han-Jin
Bae Rack-Cheon
Lee Soon-Hak
Chang Sun-Ik
Lee Hyun-Suk
Choi So-Young
Shin Keun-Young
Heo Jun
Kim Sung-Kook
Jung Min-Kyu
Jeon Seong-Woo
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Abstract
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Background/Aims: The reported prevalence of antibiotic resistance in Helicobacter pylori infection has been increasing. However, recent trends in the eradication rates of H. pylori using first-line triple regimens are rarely reported. Therefore, we determined the trend in the H. pylori eradication rates in a single center for the most recent 9 years in Daegu and Kyungpook provinces, Korea.
Methods: From January 1999 through December 2007, the eradication rates in 615 H. pylori-positive patients who received one-week triple regimens were evaluated retrospectively according to year and ulcer location. Results: The overall H. pylori eradication rate was 81.6%. The eradication rate from the years 1999 to 2007 was 76.3, 78.3, 82.8, 88.5, 77.8, 91.7, 84.8, 75.4, and 83.7%, respectively, based on the per-protocol analysis. No definite evidence of a decreasing tendency of the eradication rate was seen over the 9 years (p=0.760). Furthermore, there was no ignificant difference in the eradication rate according to ulcer location.
Conclusions: There is no decreasing trend in the H. pylori eradication rate over the past 9 years in Daegu and Kyungpook provinces. However, the eradication rates are not satisfactory, and further investigation is needed to develop more effective regimens. (Korean J Med 76:186-192, 2009)
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KEYWORD
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Helicobacter pylori, First-line regimen, Eradication rates
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